There was no way that Hermione and Ron were going to let Harry go Horcrux hunting alone. So they had to prepare.
Hermione researched, as she does, spells and potions that they would need. One of those spells helped her create her purple beaded bag with the undetectable extension charm where she put everything she thought they would need. Ranging from books, to clothes, to their tent. Hermione realized that, while she was in hiding her parents would be vulnerable so she modified their memories to forget about their life, to forget about her and sent them away to Australia.
Ron realized that his family would be targeted if he didn’t turn up to school, especially now that it was mandatory for all young witches and wizards to attend Hogwarts. Author, Fred and George managed to find Ghoul and charm it so it looked like Ron. They then made it look as though it had spattergroit, which would make him unable to attend school at all as it is contagious and effects the memory.
Harry had to convince his family, the Dursleys, to leave their home in Little Whinging and go into hiding. To go away so that they would be safe, and as Uncle Vernon continually changed his mind every 24 hours for the last 4 weeks, Harry had to constant have the same conversation and convince him that they had to go. In between each conversation, Harry cleaned out his trunk and Hedwig’s change, getting it all ready. He packed up his rucksack with clothes ready to leave. Ready to start hunting the Horcurx’s to kill Voldemort, once and for all.